1996 EXAMINATION 3
> <Q 17-24> <Q 25-32>
Select the letter of the BEST single answer.
33. Which of the following is TRUE regarding the GABA-benzodiazepine-chloride ionophore complex?
a. Barbiturates bind to a site on the GABA receptor, facilitating receptor-ligand interactions.
b. Benzodiazepines bind to a site in the chloride ion channel, increasing channel open time.
c. The influx of chloride ions depolarizes neurons, making them less excitable.
d. Benzodiazepines depend upon the action of endogenous GABA for their inhibitory action on neurotransmission..
34. Which of the following is TRUE regarding flumazenil (Romazicon®)?
A. B. C. D.
a. It has a shorter duration of action than most benzodiazepines, necessitating multiple administrations in overdose situations.
b. It is of no use in reversing the sedative actions of zolpidem (Ambien®).
c. It is useful in the treatment of barbiturate overdose.
d. It is useful for providing sedation for short surgical procedures.
35. Which of the following is NOT a property of benzodiazepines?
a. anterograde amnesia
b. anxiolytic
c. lower seizure threshold
d. muscle relaxant
36. ________would be the benzodiazepine preferred for use in an elderly patient with hepatic insufficiency.
a. chlordiazepoxide (Librium®)
b. diazepam (Valium®)
c. flurazepam (Dalmane®)
d. lorazepam (Ativan®)
37. When flurazepam (Dalmane®) is used nightly in the treatment of insomnia, significant daytime impairment develops after a week of use, because
a. of the accumulation of several active metabolites.
b. it has a very long half-life.
c. it accumulates in vessel-poor tissue.
d. none of the above.
38. Which of the following properties do barbiturates and benzodiazepines not share?
a. produce few effects on cardiovascular system
b. produce sedation
c. do not provide analgesia
d. induce liver microsomal enzymes
39. Which of the following drugs would be LEAST useful for reducing pre-operative anxiety immediately prior to surgery?
a. buspirone (BuSpar®)
b. chlordiazepoxide (Librium®)
c. diazepam (Valium®)
d. lorazepam (Ativan ®)
40. ______is a competive antagonist at the benzodiazepine receptor, meaning it binds reversibly to the receptor, but has no efficacy at the receptor.
a. diazepam (Valium®)
b. flumazenil (Romazicon®)
c. propofol (Diprivan®)
d. thiopental (Pentothal®)